Drug interactions
Butorphanol + Pimozide
Severity: Moderate
Butorphanol and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so concurrent use may increase drowsiness and psychomotor impairment. Pimozide additionally prolongs the QT interval, so any factors that compound this risk need attention.
What this interaction means in plain words
Butorphanol and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid and antipsychotic effects.
What to do
Monitor sedation and respiratory status, and check ECG and electrolytes in patients with additional QT risk factors. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Butorphanol with Pimozide?
MediHelp rates the interaction as moderate. Butorphanol and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so concurrent use may increase drowsiness and psychomotor impairment. Pimozide additionally prolongs the QT interval, so any factors that compound this risk need attention.
How serious is the interaction between Butorphanol and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and check ECG and electrolytes in patients with additional QT risk factors. Use the lowest effective doses.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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