Drug interactions
Butorphanol + Protriptyline
Severity: Moderate
Butorphanol and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can cause sedation, anticholinergic effects, and hypotension. With butorphanol these may add to CNS depression, and serotonergic effects are possible but uncommon.
What this interaction means in plain words
Butorphanol and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid activity and tricyclic antihistaminic and anticholinergic effects.
What to do
Monitor sedation, blood pressure, and anticholinergic effects, and start at low doses. Counsel on avoiding driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Protriptyline?
MediHelp rates the interaction as moderate. Butorphanol and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can cause sedation, anticholinergic effects, and hypotension. With butorphanol these may add to CNS depression, and serotonergic effects are possible but uncommon.
How serious is the interaction between Butorphanol and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure, and anticholinergic effects, and start at low doses. Counsel on avoiding driving until response is known.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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