Drug interactions
Butorphanol + Sage
Severity: Minor
Butorphanol and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage is a herbal product with some reported sedative properties, and butorphanol is an opioid agonist-antagonist that causes sedation. The combined effect on drowsiness is theoretical and the clinical significance is uncertain.
What this interaction means in plain words
Butorphanol and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effects; the mechanism for sage is not well established.
What to do
No routine change is needed; advise patients to watch for excess drowsiness when taking sage preparations with butorphanol and to avoid driving if affected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Sage?
MediHelp rates the interaction as minor. Butorphanol and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage is a herbal product with some reported sedative properties, and butorphanol is an opioid agonist-antagonist that causes sedation. The combined effect on drowsiness is theoretical and the clinical significance is uncertain.
How serious is the interaction between Butorphanol and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to watch for excess drowsiness when taking sage preparations with butorphanol and to avoid driving if affected.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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