Drug interactions
Butorphanol + Trifluoperazine
Severity: Moderate
Butorphanol and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as trifluoperazine can cause sedation and hypotension. With butorphanol these effects may add, increasing risk of oversedation and falls.
What this interaction means in plain words
Butorphanol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension from opioid agonism and antipsychotic receptor blockade.
What to do
Start with reduced doses and monitor sedation and blood pressure. Caution in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Trifluoperazine?
MediHelp rates the interaction as moderate. Butorphanol and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as trifluoperazine can cause sedation and hypotension. With butorphanol these effects may add, increasing risk of oversedation and falls.
How serious is the interaction between Butorphanol and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses and monitor sedation and blood pressure. Caution in elderly patients.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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