Drug interactions
Butorphanol + Zotepine
Severity: Moderate
Butorphanol and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butorphanol is an opioid agonist-antagonist and zotepine is a sedating antipsychotic. Used together they can cause additive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression and hypotension.
What this interaction means in plain words
Butorphanol and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from opioid activity and antipsychotic antihistaminic and antiadrenergic effects.
What to do
Start with the lowest effective doses of both drugs and monitor sedation and respiratory rate, especially in elderly patients. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Zotepine?
MediHelp rates the interaction as moderate. Butorphanol and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butorphanol is an opioid agonist-antagonist and zotepine is a sedating antipsychotic. Used together they can cause additive drowsiness, impaired psychomotor performance and, at higher doses, respiratory depression and hypotension.
How serious is the interaction between Butorphanol and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses of both drugs and monitor sedation and respiratory rate, especially in elderly patients. Advise patients to avoid driving and alcohol.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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