Drug interactions
Cabergoline + Indinavir
Severity: Moderate
Cabergoline and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 inhibitor that may increase cabergoline concentrations. Raised ergot exposure could lead to adverse effects such as hypotension, nausea, and vasospasm. Documentation specific to cabergoline is limited.
What this interaction means in plain words
Cabergoline and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cabergoline.
What to do
Start with a low cabergoline dose and titrate slowly while monitoring blood pressure and adverse effects, or choose an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Indinavir?
MediHelp rates the interaction as moderate. Cabergoline and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a CYP3A4 inhibitor that may increase cabergoline concentrations. Raised ergot exposure could lead to adverse effects such as hypotension, nausea, and vasospasm. Documentation specific to cabergoline is limited.
How serious is the interaction between Cabergoline and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low cabergoline dose and titrate slowly while monitoring blood pressure and adverse effects, or choose an alternative agent.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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