Drug interactions
Cabergoline + Lisuride
Severity: Moderate
Cabergoline and Lisuride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are ergot-derived dopamine agonists, so combined use adds to dopaminergic effects such as nausea, hypotension, somnolence and psychiatric symptoms. Cumulative ergot exposure also adds to the risk of fibrotic reactions, including cardiac valvulopathy, with long-term use.
What this interaction means in plain words
Cabergoline and Lisuride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine receptor agonism, with shared ergot-related serotonin 5-HT2B agonist effects.
What to do
Avoid duplicate dopamine agonist therapy where possible and use the lowest effective doses. Monitor blood pressure, mental status and cardiac status, including echocardiography with prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Lisuride?
MediHelp rates the interaction as moderate. Cabergoline and Lisuride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are ergot-derived dopamine agonists, so combined use adds to dopaminergic effects such as nausea, hypotension, somnolence and psychiatric symptoms. Cumulative ergot exposure also adds to the risk of fibrotic reactions, including cardiac valvulopathy, with long-term use.
How serious is the interaction between Cabergoline and Lisuride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate dopamine agonist therapy where possible and use the lowest effective doses. Monitor blood pressure, mental status and cardiac status, including echocardiography with prolonged use.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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