Drug interactions
Cabergoline + Metoclopramide intranasal
Severity: Major
Cabergoline and Metoclopramide intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabergoline is a dopamine agonist and metoclopramide is a dopamine D2 antagonist, so they oppose each other. This can reduce the effect of cabergoline, for example on prolactin lowering, and can worsen parkinsonian symptoms.
What this interaction means in plain words
Cabergoline and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination and use a non-dopamine-blocking antiemetic or prokinetic such as domperidone where appropriate. If unavoidable, monitor prolactin levels and motor symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Metoclopramide intranasal?
MediHelp rates the interaction as major. Cabergoline and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cabergoline is a dopamine agonist and metoclopramide is a dopamine D2 antagonist, so they oppose each other. This can reduce the effect of cabergoline, for example on prolactin lowering, and can worsen parkinsonian symptoms.
How serious is the interaction between Cabergoline and Metoclopramide intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-dopamine-blocking antiemetic or prokinetic such as domperidone where appropriate. If unavoidable, monitor prolactin levels and motor symptoms.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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