Drug interactions
Cabergoline + Sumatriptan intranasal
Severity: Moderate
Cabergoline and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabergoline is an ergot derivative with vasoconstrictive potential, and sumatriptan is a vasoconstricting 5-HT1B/1D agonist. Using them close together may cause additive vasospasm, although cabergoline's vasospastic effect is weaker than that of ergotamine.
What this interaction means in plain words
Cabergoline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasoconstriction through serotonergic receptor agonism.
What to do
Separate doses by at least 24 hours when feasible and monitor for chest pain, limb ischemia or hypertension. Avoid in patients with coronary or peripheral vascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Cabergoline and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabergoline is an ergot derivative with vasoconstrictive potential, and sumatriptan is a vasoconstricting 5-HT1B/1D agonist. Using them close together may cause additive vasospasm, although cabergoline's vasospastic effect is weaker than that of ergotamine.
How serious is the interaction between Cabergoline and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 24 hours when feasible and monitor for chest pain, limb ischemia or hypertension. Avoid in patients with coronary or peripheral vascular disease.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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