Drug interactions
Cabergoline + Yohimbine
Severity: Moderate
Cabergoline and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises noradrenergic activity and can cause hypertension and tachycardia. Cabergoline may add vasoconstrictive effects, so pressor responses could be exaggerated.
What this interaction means in plain words
Cabergoline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pressor effects from alpha-2 blockade-driven noradrenergic increase and ergoline vasoconstriction.
What to do
Avoid yohimbine in patients with hypertension, and monitor blood pressure if used with cabergoline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Yohimbine?
MediHelp rates the interaction as moderate. Cabergoline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises noradrenergic activity and can cause hypertension and tachycardia. Cabergoline may add vasoconstrictive effects, so pressor responses could be exaggerated.
How serious is the interaction between Cabergoline and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine in patients with hypertension, and monitor blood pressure if used with cabergoline.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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