Drug interactions
Cabozantinib + Dichlorphenamide
Severity: Moderate
Cabozantinib and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabozantinib can cause diarrhea and electrolyte disturbances including hypokalemia, and dichlorphenamide adds renal potassium loss. Together hypokalemia may be more likely, which is relevant given cabozantinib's QT effects.
What this interaction means in plain words
Cabozantinib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive potassium loss from renal wasting due to carbonic anhydrase inhibition and gastrointestinal or other losses with cabozantinib.
What to do
Monitor serum potassium and bicarbonate periodically and correct deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Dichlorphenamide?
MediHelp rates the interaction as moderate. Cabozantinib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabozantinib can cause diarrhea and electrolyte disturbances including hypokalemia, and dichlorphenamide adds renal potassium loss. Together hypokalemia may be more likely, which is relevant given cabozantinib's QT effects.
How serious is the interaction between Cabozantinib and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate periodically and correct deficits promptly.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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