Drug interactions
Cabozantinib + Diltiazem
Severity: Moderate
Cabozantinib and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem, a moderate CYP3A4 inhibitor, may raise cabozantinib exposure. This could increase adverse effects such as diarrhea, hypertension, hand-foot syndrome and bleeding.
What this interaction means in plain words
Cabozantinib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by diltiazem reduces cabozantinib clearance.
What to do
Monitor for cabozantinib toxicity and blood pressure, and reduce the dose or interrupt treatment if adverse effects emerge. Consider a non-CYP3A4-inhibiting alternative for the antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Diltiazem?
MediHelp rates the interaction as moderate. Cabozantinib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem, a moderate CYP3A4 inhibitor, may raise cabozantinib exposure. This could increase adverse effects such as diarrhea, hypertension, hand-foot syndrome and bleeding.
How serious is the interaction between Cabozantinib and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib toxicity and blood pressure, and reduce the dose or interrupt treatment if adverse effects emerge. Consider a non-CYP3A4-inhibiting alternative for the antihypertensive.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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