Drug interactions
Cabozantinib + Isoniazid
Severity: Moderate
Cabozantinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and increase cabozantinib exposure, with potential for diarrhea, hypertension, palmar-plantar erythrodysesthesia and hepatotoxicity. Isoniazid adds hepatotoxic potential.
What this interaction means in plain words
Cabozantinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, decreasing cabozantinib metabolism, with additive hepatotoxicity.
What to do
Monitor liver tests, blood pressure and adverse effects, and reduce the cabozantinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Isoniazid?
MediHelp rates the interaction as moderate. Cabozantinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and increase cabozantinib exposure, with potential for diarrhea, hypertension, palmar-plantar erythrodysesthesia and hepatotoxicity. Isoniazid adds hepatotoxic potential.
How serious is the interaction between Cabozantinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests, blood pressure and adverse effects, and reduce the cabozantinib dose if toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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