Drug interactions
Cabozantinib + Metronidazole
Severity: Minor
Cabozantinib and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is a weak CYP3A4 inhibitor, so a meaningful increase in cabozantinib exposure is unlikely. Only strong CYP3A4 inhibitors have documented relevance for cabozantinib dosing.
What this interaction means in plain words
Cabozantinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cabozantinib belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Weak CYP3A4 inhibition by metronidazole may slightly reduce cabozantinib metabolism.
What to do
No dose change is needed; monitor for cabozantinib toxicities such as diarrhea, hypertension and hand-foot syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cabozantinib and Metronidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Metronidazole?
MediHelp rates the interaction as minor. Cabozantinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is a weak CYP3A4 inhibitor, so a meaningful increase in cabozantinib exposure is unlikely. Only strong CYP3A4 inhibitors have documented relevance for cabozantinib dosing.
How serious is the interaction between Cabozantinib and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for cabozantinib toxicities such as diarrhea, hypertension and hand-foot syndrome.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
