Drug interactions
Calcium citrate + Hydrochlorothiazide-olmesartan
Severity: Moderate
Calcium citrate and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, so calcium supplements may raise serum calcium. Hypercalcemia is more likely with high calcium doses, vitamin D, or reduced renal function.
What this interaction means in plain words
Calcium citrate and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides increase distal tubular calcium reabsorption, reducing renal calcium clearance.
What to do
Monitor serum calcium periodically, especially in renal impairment or with concurrent vitamin D. Reduce the calcium dose or switch the diuretic if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Calcium citrate with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Calcium citrate and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, so calcium supplements may raise serum calcium. Hypercalcemia is more likely with high calcium doses, vitamin D, or reduced renal function.
How serious is the interaction between Calcium citrate and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially in renal impairment or with concurrent vitamin D. Reduce the calcium dose or switch the diuretic if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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