Drug interactions
Calcium citrate + Hydrocortisone
Severity: Minor
Calcium citrate and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids reduce intestinal calcium absorption and increase urinary calcium loss. With long-term use, calcium supplementation may be less effective at protecting bone.
What this interaction means in plain words
Calcium citrate and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroids reduce vitamin D-dependent intestinal calcium absorption and increase renal calcium excretion.
What to do
Continue calcium and vitamin D supplementation during prolonged steroid therapy and assess bone density when indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Calcium citrate with Hydrocortisone?
MediHelp rates the interaction as minor. Calcium citrate and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids reduce intestinal calcium absorption and increase urinary calcium loss. With long-term use, calcium supplementation may be less effective at protecting bone.
How serious is the interaction between Calcium citrate and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue calcium and vitamin D supplementation during prolonged steroid therapy and assess bone density when indicated.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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