Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Oxazepam
Severity: Contraindicated
Calcium / magnesium / potassium / sodium oxybates and Oxazepam: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates combined with benzodiazepines cause additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Concomitant use with sedative hypnotics is restricted in labeling.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Oxazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive CNS depression via GABA-B agonism by oxybate and GABA-A potentiation by oxazepam.
What to do
Avoid the combination; if a benzodiazepine is essential, consider an alternative to oxybate or stop one drug. Monitor respiratory status if unavoidable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxazepam
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
- Benzhydrocodone / acetaminophen + Oxazepam Major
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Oxazepam?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Oxazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates combined with benzodiazepines cause additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Concomitant use with sedative hypnotics is restricted in labeling.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Oxazepam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a benzodiazepine is essential, consider an alternative to oxybate or stop one drug. Monitor respiratory status if unavoidable.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Sodium oxybate, Alfentanil, Amobarbital. The full list is on the Oxazepam page.
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