Drug interactions
Cannabidiol + Sodium valproate
Severity: Major
Cannabidiol and Sodium valproate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
What this interaction means in plain words
Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cannabidiol belongs to Central Nervous System; Sodium valproate belongs to Central Nervous System.
Why it happens
Probably additive hepatotoxicity; the exact mechanism is not established.
What to do
Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
- Amobarbital + Cannabidiol Moderate
Other interactions of Sodium valproate
Frequently asked questions
Can I take Cannabidiol with Sodium valproate?
MediHelp rates the interaction as major. Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
How serious is the interaction between Cannabidiol and Sodium valproate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Tacrolimus, Abiraterone. The full list is on the Cannabidiol page.
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