Drug interactions
Capreomycin + Carboplatin
Severity: Major
Capreomycin and Carboplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the kidney and the inner ear. Using them together may increase the risk of renal impairment, hearing loss and electrolyte disturbances such as hypokalemia and hypomagnesemia.
What this interaction means in plain words
Capreomycin and Carboplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity and ototoxicity.
What to do
Avoid the combination if an alternative exists. If required, monitor creatinine, electrolytes and hearing, and adjust doses to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carboplatin
Frequently asked questions
Can I take Capreomycin with Carboplatin?
MediHelp rates the interaction as major. Capreomycin and Carboplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the kidney and the inner ear. Using them together may increase the risk of renal impairment, hearing loss and electrolyte disturbances such as hypokalemia and hypomagnesemia.
How serious is the interaction between Capreomycin and Carboplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If required, monitor creatinine, electrolytes and hearing, and adjust doses to renal function.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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