Drug interactions
Capreomycin + Dichlorphenamide
Severity: Moderate
Capreomycin and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and capreomycin can also cause renal tubular wasting of potassium and magnesium. Combined use may produce clinically significant hypokalemia, which can lead to weakness and arrhythmias.
What this interaction means in plain words
Capreomycin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium loss through renal bicarbonate and potassium wasting with dichlorphenamide and tubular toxicity with capreomycin.
What to do
Monitor serum potassium and magnesium at baseline and regularly during combined therapy. Replace electrolytes as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Capreomycin with Dichlorphenamide?
MediHelp rates the interaction as moderate. Capreomycin and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and capreomycin can also cause renal tubular wasting of potassium and magnesium. Combined use may produce clinically significant hypokalemia, which can lead to weakness and arrhythmias.
How serious is the interaction between Capreomycin and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium at baseline and regularly during combined therapy. Replace electrolytes as needed.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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