Drug interactions
Capreomycin + Tenofovir disoproxil
Severity: Major
Capreomycin and Tenofovir disoproxil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the kidneys, and capreomycin is also ototoxic. Combined use may cause additive renal injury and increase tenofovir exposure.
What this interaction means in plain words
Capreomycin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of tenofovir as kidney function declines.
What to do
Avoid the combination if alternatives exist. If unavoidable, monitor creatinine, electrolytes and phosphate frequently and assess hearing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Frequently asked questions
Can I take Capreomycin with Tenofovir disoproxil?
MediHelp rates the interaction as major. Capreomycin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the kidneys, and capreomycin is also ototoxic. Combined use may cause additive renal injury and increase tenofovir exposure.
How serious is the interaction between Capreomycin and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if alternatives exist. If unavoidable, monitor creatinine, electrolytes and phosphate frequently and assess hearing.
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