Drug interactions
Capsicum + Enalapril
Severity: Minor
Capsicum and Enalapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capsaicin-containing products, particularly when taken orally, may provoke cough, which could add to or be confused with ACE inhibitor-induced cough. The effect is mainly a nuisance and is not expected to alter enalapril efficacy.
What this interaction means in plain words
Capsicum and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Both agents may sensitize airway cough reflexes, partly via sensory neuropeptide and bradykinin/substance P pathways.
What to do
If new or worsening cough develops, consider capsicum as a contributor before changing enalapril therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Capsicum with Enalapril?
MediHelp rates the interaction as minor. Capsicum and Enalapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capsaicin-containing products, particularly when taken orally, may provoke cough, which could add to or be confused with ACE inhibitor-induced cough. The effect is mainly a nuisance and is not expected to alter enalapril efficacy.
How serious is the interaction between Capsicum and Enalapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If new or worsening cough develops, consider capsicum as a contributor before changing enalapril therapy.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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