Drug interactions
Captopril + Conivaptan
Severity: Moderate
Captopril and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan, a vasopressin antagonist, causes aquaresis and can occasionally lead to hypovolemia and hypotension. Together with captopril, blood pressure may fall further, and overly rapid sodium rise is a separate concern with conivaptan.
What this interaction means in plain words
Captopril and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from aquaresis-related volume loss and ACE inhibition.
What to do
Monitor blood pressure, volume status and serum sodium during conivaptan therapy. Adjust captopril if hypotension or hypovolemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Conivaptan?
MediHelp rates the interaction as moderate. Captopril and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan, a vasopressin antagonist, causes aquaresis and can occasionally lead to hypovolemia and hypotension. Together with captopril, blood pressure may fall further, and overly rapid sodium rise is a separate concern with conivaptan.
How serious is the interaction between Captopril and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status and serum sodium during conivaptan therapy. Adjust captopril if hypotension or hypovolemia develops.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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