Drug interactions
Captopril + Dextroamphetamine
Severity: Moderate
Captopril and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine has sympathomimetic effects that raise blood pressure and can reduce the control achieved with captopril. Hypertensive control may deteriorate during stimulant therapy.
What this interaction means in plain words
Captopril and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: amphetamine-induced norepinephrine release and vasoconstriction oppose ACE inhibitor vasodilation.
What to do
Monitor blood pressure regularly after starting or changing the stimulant dose. Increase antihypertensive therapy or reconsider the stimulant if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril with Dextroamphetamine?
MediHelp rates the interaction as moderate. Captopril and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine has sympathomimetic effects that raise blood pressure and can reduce the control achieved with captopril. Hypertensive control may deteriorate during stimulant therapy.
How serious is the interaction between Captopril and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly after starting or changing the stimulant dose. Increase antihypertensive therapy or reconsider the stimulant if blood pressure rises.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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