Drug interactions
Captopril + Doxazosin
Severity: Moderate
Captopril and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lower blood pressure and the combination can cause an exaggerated first-dose hypotensive response. Patients who are volume depleted or elderly are at greater risk of dizziness and syncope.
What this interaction means in plain words
Captopril and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade and inhibition of angiotensin II formation.
What to do
Start the added drug at a low dose, ideally at bedtime, and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Doxazosin?
MediHelp rates the interaction as moderate. Captopril and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both lower blood pressure and the combination can cause an exaggerated first-dose hypotensive response. Patients who are volume depleted or elderly are at greater risk of dizziness and syncope.
How serious is the interaction between Captopril and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the added drug at a low dose, ideally at bedtime, and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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