Drug interactions
Captopril + Empagliflozin-linagliptin
Severity: Moderate
Captopril and Empagliflozin-linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors such as linagliptin may increase the risk of angioedema in patients taking ACE inhibitors, because both reduce breakdown of peptides involved in angioedema. The absolute risk is low but the event can be serious.
What this interaction means in plain words
Captopril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Empagliflozin-linagliptin belongs to Endocrine.
Why it happens
Both drug classes inhibit enzymes (ACE and DPP-4) that degrade bradykinin and substance P, so additive peptide accumulation may promote angioedema.
What to do
Counsel the patient to seek urgent care for facial, lip or tongue swelling. Stop the offending drugs if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Captopril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as linagliptin may increase the risk of angioedema in patients taking ACE inhibitors, because both reduce breakdown of peptides involved in angioedema. The absolute risk is low but the event can be serious.
How serious is the interaction between Captopril and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to seek urgent care for facial, lip or tongue swelling. Stop the offending drugs if angioedema occurs.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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