Drug interactions
Captopril + Ferric gluconate
Severity: Minor
Captopril and Ferric gluconate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous iron can cause hypersensitivity-type reactions and transient hypotension, flushing and nausea. ACE inhibitors have been reported to potentiate such systemic reactions, though the evidence is limited.
What this interaction means in plain words
Captopril and Ferric gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not firmly established; possible reduced compensation for iron-induced vasodilatory reactions during ACE inhibition.
What to do
Administer ferric gluconate slowly and monitor blood pressure and symptoms during and after infusion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Ferric gluconate?
MediHelp rates the interaction as minor. Captopril and Ferric gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intravenous iron can cause hypersensitivity-type reactions and transient hypotension, flushing and nausea. ACE inhibitors have been reported to potentiate such systemic reactions, though the evidence is limited.
How serious is the interaction between Captopril and Ferric gluconate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer ferric gluconate slowly and monitor blood pressure and symptoms during and after infusion.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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