Drug interactions
Captopril + Insulin aspart
Severity: Moderate
Captopril and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin. Hypoglycemia is more likely after starting captopril in insulin-treated patients.
What this interaction means in plain words
Captopril and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Insulin aspart belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, adding to the glucose-lowering effect of exogenous insulin.
What to do
Monitor blood glucose more frequently when captopril is started or the dose is changed. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Insulin aspart
Frequently asked questions
Can I take Captopril with Insulin aspart?
MediHelp rates the interaction as moderate. Captopril and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin. Hypoglycemia is more likely after starting captopril in insulin-treated patients.
How serious is the interaction between Captopril and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when captopril is started or the dose is changed. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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