Drug interactions
Captopril + Insulin degludec / insulin aspart
Severity: Moderate
Captopril and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been associated with increased hypoglycemia in patients taking insulin. The effect is usually modest but can be important in those with tight glycemic control or variable intake.
What this interaction means in plain words
Captopril and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition may enhance insulin sensitivity and glucose uptake, adding to the effect of exogenous insulin.
What to do
Monitor blood glucose more frequently after starting captopril and reduce the insulin dose if hypoglycemia occurs. Educate patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Captopril and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been associated with increased hypoglycemia in patients taking insulin. The effect is usually modest but can be important in those with tight glycemic control or variable intake.
How serious is the interaction between Captopril and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting captopril and reduce the insulin dose if hypoglycemia occurs. Educate patients on hypoglycemia symptoms.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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