Drug interactions
Captopril + Iron dextran complex
Severity: Moderate
Captopril and Iron dextran complex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase the risk or severity of hypersensitivity-type reactions to parenteral iron dextran. Anaphylactoid reactions can be serious and occur during or shortly after infusion.
What this interaction means in plain words
Captopril and Iron dextran complex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Not well established; ACE inhibition may impair breakdown of mediators involved in anaphylactoid reactions.
What to do
Give iron dextran only where resuscitation facilities are available and observe the patient after administration. Consider an alternative IV iron product or temporarily withholding the ACE inhibitor when clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Iron dextran complex?
MediHelp rates the interaction as moderate. Captopril and Iron dextran complex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase the risk or severity of hypersensitivity-type reactions to parenteral iron dextran. Anaphylactoid reactions can be serious and occur during or shortly after infusion.
How serious is the interaction between Captopril and Iron dextran complex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give iron dextran only where resuscitation facilities are available and observe the patient after administration. Consider an alternative IV iron product or temporarily withholding the ACE inhibitor when clinically feasible.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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