Drug interactions
Captopril + Ketorolac intranasal
Severity: Major
Captopril and Ketorolac intranasal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use and as an NSAID can reduce the antihypertensive effect of captopril and impair renal function. The risk of acute kidney injury and hyperkalemia is higher with volume depletion, advanced age or renal disease.
What this interaction means in plain words
Captopril and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor effects.
What to do
Avoid or limit the duration of ketorolac and use a non-NSAID analgesic where possible. If used, ensure hydration and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Ketorolac intranasal?
MediHelp rates the interaction as major. Captopril and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is absorbed systemically after intranasal use and as an NSAID can reduce the antihypertensive effect of captopril and impair renal function. The risk of acute kidney injury and hyperkalemia is higher with volume depletion, advanced age or renal disease.
How serious is the interaction between Captopril and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit the duration of ketorolac and use a non-NSAID analgesic where possible. If used, ensure hydration and monitor blood pressure, creatinine and potassium.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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