Drug interactions
Captopril + Lorcaserin
Severity: Minor
Captopril and Lorcaserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a weak CYP2D6 inhibitor, and captopril is partly metabolized by CYP2D6. A clinically meaningful rise in captopril exposure is not established and captopril's effect is largely independent of its metabolism.
What this interaction means in plain words
Captopril and Lorcaserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP2D6 by lorcaserin could slightly reduce captopril metabolism.
What to do
No dose change is generally needed; monitor blood pressure as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Lorcaserin?
MediHelp rates the interaction as minor. Captopril and Lorcaserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorcaserin is a weak CYP2D6 inhibitor, and captopril is partly metabolized by CYP2D6. A clinically meaningful rise in captopril exposure is not established and captopril's effect is largely independent of its metabolism.
How serious is the interaction between Captopril and Lorcaserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor blood pressure as usual.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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