Drug interactions
Captopril + Magnesium salicylate
Severity: Moderate
Captopril and Magnesium salicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs including salicylates can impair renal function when combined with ACE inhibitors, especially in elderly or volume-depleted patients. They may also blunt the antihypertensive effect of captopril.
What this interaction means in plain words
Captopril and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis reduces renal perfusion and counteracts ACE inhibitor effects on blood pressure and glomerular filtration.
What to do
Maintain hydration and monitor serum creatinine, potassium and blood pressure, particularly in older or volume-depleted patients. Prefer a non-NSAID analgesic such as paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Magnesium salicylate?
MediHelp rates the interaction as moderate. Captopril and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs including salicylates can impair renal function when combined with ACE inhibitors, especially in elderly or volume-depleted patients. They may also blunt the antihypertensive effect of captopril.
How serious is the interaction between Captopril and Magnesium salicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor serum creatinine, potassium and blood pressure, particularly in older or volume-depleted patients. Prefer a non-NSAID analgesic such as paracetamol where possible.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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