Drug interactions
Captopril + Meclofenamate
Severity: Moderate
Captopril and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce the antihypertensive effect of captopril and increase the risk of acute kidney injury and hyperkalemia. Risk is greatest in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Captopril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor effects.
What to do
Use the lowest NSAID dose for the shortest time or choose paracetamol. Monitor blood pressure, creatinine and potassium and keep the patient hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Meclofenamate?
MediHelp rates the interaction as moderate. Captopril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce the antihypertensive effect of captopril and increase the risk of acute kidney injury and hyperkalemia. Risk is greatest in older, volume-depleted or renally impaired patients.
How serious is the interaction between Captopril and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time or choose paracetamol. Monitor blood pressure, creatinine and potassium and keep the patient hydrated.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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