Drug interactions
Captopril + Metformin-sitagliptin
Severity: Moderate
Captopril and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance glucose lowering and rarely contribute to hypoglycemia in diabetic patients. Sitagliptin combined with an ACE inhibitor may increase the risk of angioedema, and any decline in renal function raises metformin risk.
What this interaction means in plain words
Captopril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
ACE inhibitors improve insulin sensitivity and, with DPP-4 inhibitors, reduce breakdown of bradykinin and substance P, adding to angioedema risk.
What to do
Monitor blood glucose and renal function. Advise the patient to seek urgent care for facial or tongue swelling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril and Metformin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Captopril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance glucose lowering and rarely contribute to hypoglycemia in diabetic patients. Sitagliptin combined with an ACE inhibitor may increase the risk of angioedema, and any decline in renal function raises metformin risk.
How serious is the interaction between Captopril and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function. Advise the patient to seek urgent care for facial or tongue swelling.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
