Drug interactions
Captopril + Nitric oxide gas
Severity: Minor
Captopril and Nitric oxide gas: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled nitric oxide is a pulmonary vasodilator with limited systemic effect, but it may produce some systemic hypotension. Additive blood pressure lowering with captopril is possible, though clinically minor.
What this interaction means in plain words
Captopril and Nitric oxide gas have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive vasodilatory effects.
What to do
Monitor blood pressure during nitric oxide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Nitric oxide gas?
MediHelp rates the interaction as minor. Captopril and Nitric oxide gas have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled nitric oxide is a pulmonary vasodilator with limited systemic effect, but it may produce some systemic hypotension. Additive blood pressure lowering with captopril is possible, though clinically minor.
How serious is the interaction between Captopril and Nitric oxide gas?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during nitric oxide therapy.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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