Drug interactions
Captopril + Nitroglycerin po
Severity: Moderate
Captopril and Nitroglycerin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates and ACE inhibitors both lower blood pressure, so combined use can cause additive hypotension, dizziness or syncope. The combination is often used intentionally in cardiac disease.
What this interaction means in plain words
Captopril and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide-mediated venodilation and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug, and counsel the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Nitroglycerin po?
MediHelp rates the interaction as moderate. Captopril and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates and ACE inhibitors both lower blood pressure, so combined use can cause additive hypotension, dizziness or syncope. The combination is often used intentionally in cardiac disease.
How serious is the interaction between Captopril and Nitroglycerin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug, and counsel the patient to rise slowly.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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