Drug interactions
Captopril + Olanzapine
Severity: Moderate
Captopril and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension through alpha-1 blockade, which can add to the blood pressure lowering of captopril. Dizziness, syncope and falls may occur, particularly early in treatment.
What this interaction means in plain words
Captopril and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Olanzapine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms during initiation and dose changes. Lower the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Captopril with Olanzapine?
MediHelp rates the interaction as moderate. Captopril and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension through alpha-1 blockade, which can add to the blood pressure lowering of captopril. Dizziness, syncope and falls may occur, particularly early in treatment.
How serious is the interaction between Captopril and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during initiation and dose changes. Lower the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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