Drug interactions
Captopril + Pentobarbital
Severity: Moderate
Captopril and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can lower blood pressure, especially when given intravenously or at sedative doses, and may add to the effect of captopril. Orthostatic hypotension may result.
What this interaction means in plain words
Captopril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from CNS depression and vasodilation with ACE inhibition.
What to do
Monitor blood pressure during pentobarbital use and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Pentobarbital?
MediHelp rates the interaction as moderate. Captopril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can lower blood pressure, especially when given intravenously or at sedative doses, and may add to the effect of captopril. Orthostatic hypotension may result.
How serious is the interaction between Captopril and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during pentobarbital use and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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