Drug interactions
Captopril + Potassium citrate-citric acid
Severity: Moderate
Captopril and Potassium citrate-citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril lowers aldosterone production and thereby decreases potassium excretion, while potassium citrate supplies additional potassium. The combination can lead to hyperkalemia, especially with kidney disease or diabetes.
What this interaction means in plain words
Captopril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Potassium citrate-citric acid belongs to Gastrointestinal Tract.
Why it happens
ACE inhibition reduces angiotensin II and aldosterone, decreasing renal potassium excretion on top of the supplemental potassium.
What to do
Monitor serum potassium and creatinine at baseline and regularly during combined therapy. Adjust or stop the potassium supplement if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Potassium citrate-citric acid
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Potassium citrate-citric acid?
MediHelp rates the interaction as moderate. Captopril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Captopril lowers aldosterone production and thereby decreases potassium excretion, while potassium citrate supplies additional potassium. The combination can lead to hyperkalemia, especially with kidney disease or diabetes.
How serious is the interaction between Captopril and Potassium citrate-citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine at baseline and regularly during combined therapy. Adjust or stop the potassium supplement if hyperkalemia develops.
What other medicines interact with Potassium citrate-citric acid?
MediHelp also lists interactions of Potassium citrate-citric acid with, for example, Amiloride, Eplerenone, Finerenone. The full list is on the Potassium citrate-citric acid page.
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