Drug interactions
Captopril + Promazine
Severity: Minor
Captopril and Promazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine with alpha-adrenergic blocking activity that can cause orthostatic hypotension. With captopril the blood pressure lowering may be enhanced.
What this interaction means in plain words
Captopril and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects from alpha-blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Promazine?
MediHelp rates the interaction as minor. Captopril and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promazine is a phenothiazine with alpha-adrenergic blocking activity that can cause orthostatic hypotension. With captopril the blood pressure lowering may be enhanced.
How serious is the interaction between Captopril and Promazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, particularly in older patients.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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