Drug interactions
Captopril + Remifentanil
Severity: Moderate
Captopril and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remifentanil can cause hypotension and bradycardia, and captopril lowers blood pressure, so combined use may produce a larger fall in blood pressure. The effect is most relevant during anesthesia.
What this interaction means in plain words
Captopril and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from ACE inhibition and opioid-induced vasodilation and bradycardia.
What to do
Monitor blood pressure and heart rate closely, adjust the remifentanil rate, and treat hypotension with fluids or vasopressors as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Remifentanil?
MediHelp rates the interaction as moderate. Captopril and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remifentanil can cause hypotension and bradycardia, and captopril lowers blood pressure, so combined use may produce a larger fall in blood pressure. The effect is most relevant during anesthesia.
How serious is the interaction between Captopril and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely, adjust the remifentanil rate, and treat hypotension with fluids or vasopressors as needed.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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