Drug interactions
Captopril + Salicylates
Severity: Minor
Captopril and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylsalicylate salicylates can inhibit prostaglandin synthesis and may blunt the antihypertensive effect of captopril. They may also impair renal function when combined with ACE inhibitors, particularly with volume depletion. The effect is usually small with low-dose or short-term use.
What this interaction means in plain words
Captopril and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of prostaglandin synthesis reduces renal vasodilation and sodium excretion, antagonizing ACE inhibitor effects.
What to do
Monitor blood pressure and renal function if regular or high-dose salicylates are used, and keep patients well hydrated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Salicylates?
MediHelp rates the interaction as minor. Captopril and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylsalicylate salicylates can inhibit prostaglandin synthesis and may blunt the antihypertensive effect of captopril. They may also impair renal function when combined with ACE inhibitors, particularly with volume depletion. The effect is usually small with low-dose or short-term use.
How serious is the interaction between Captopril and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if regular or high-dose salicylates are used, and keep patients well hydrated.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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