Drug interactions
Captopril + Salsalate
Severity: Moderate
Captopril and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate with relatively weak prostaglandin inhibition, but at anti-inflammatory doses it may blunt the effect of captopril and affect renal function. The risk is higher in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Captopril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal prostaglandin synthesis opposes ACE inhibitor-mediated vasodilation and renal perfusion.
What to do
Monitor blood pressure, creatinine and potassium during combined use, particularly at higher salsalate doses. Maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Salsalate?
MediHelp rates the interaction as moderate. Captopril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate with relatively weak prostaglandin inhibition, but at anti-inflammatory doses it may blunt the effect of captopril and affect renal function. The risk is higher in older, dehydrated or renally impaired patients.
How serious is the interaction between Captopril and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium during combined use, particularly at higher salsalate doses. Maintain hydration.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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