Drug interactions
Captopril + Serdexmethylphenidate / dexmethylphenidate
Severity: Moderate
Captopril and Serdexmethylphenidate / dexmethylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants such as methylphenidate can raise blood pressure and heart rate. This may partly offset the antihypertensive effect of captopril in treated patients.
What this interaction means in plain words
Captopril and Serdexmethylphenidate / dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic pressor effect of the stimulant opposes ACE inhibitor blood pressure lowering.
What to do
Monitor blood pressure regularly after starting or changing the stimulant dose. Adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as moderate. Captopril and Serdexmethylphenidate / dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stimulants such as methylphenidate can raise blood pressure and heart rate. This may partly offset the antihypertensive effect of captopril in treated patients.
How serious is the interaction between Captopril and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly after starting or changing the stimulant dose. Adjust the antihypertensive regimen if control is lost.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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