Drug interactions
Captopril + Sildenafil
Severity: Moderate
Captopril and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure by different mechanisms. Taken together they may cause additive hypotension, particularly on initiation or after dose increases.
What this interaction means in plain words
Captopril and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilatory and hypotensive effects of PDE5 inhibition and ACE inhibition.
What to do
Begin with a low sildenafil dose in patients on captopril and monitor blood pressure and orthostatic symptoms. Counsel patients to report dizziness or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Sildenafil?
MediHelp rates the interaction as moderate. Captopril and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure by different mechanisms. Taken together they may cause additive hypotension, particularly on initiation or after dose increases.
How serious is the interaction between Captopril and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with a low sildenafil dose in patients on captopril and monitor blood pressure and orthostatic symptoms. Counsel patients to report dizziness or syncope.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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