Drug interactions
Captopril + Sodium citrate / citric acid
Severity: Minor
Captopril and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate-based alkalinizing solutions are thought to possibly reduce captopril absorption, though supporting data are limited. Any loss of antihypertensive effect would likely be small.
What this interaction means in plain words
Captopril and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduced gastrointestinal absorption of captopril; mechanism is not well established.
What to do
Give captopril at least 2 hours apart from the citrate solution and check blood pressure if used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Captopril and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate-based alkalinizing solutions are thought to possibly reduce captopril absorption, though supporting data are limited. Any loss of antihypertensive effect would likely be small.
How serious is the interaction between Captopril and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give captopril at least 2 hours apart from the citrate solution and check blood pressure if used regularly.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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