Drug interactions
Captopril + Sulfasalazine
Severity: Minor
Captopril and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not a significant NSAID-type prostaglandin inhibitor, so the antagonism of captopril described by class is unlikely to apply. No well-established clinical interaction exists beyond rare reports of blood dyscrasias common to both drugs.
What this interaction means in plain words
Captopril and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No clear mechanism; possible additive hematologic or renal effects are theoretical.
What to do
No routine change is needed. Monitor blood counts and renal function as part of standard follow-up.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Sulfasalazine?
MediHelp rates the interaction as minor. Captopril and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not a significant NSAID-type prostaglandin inhibitor, so the antagonism of captopril described by class is unlikely to apply. No well-established clinical interaction exists beyond rare reports of blood dyscrasias common to both drugs.
How serious is the interaction between Captopril and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor blood counts and renal function as part of standard follow-up.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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