Drug interactions
Captopril + Synthetic human angiotensin ii
Severity: Moderate
Captopril and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients on ACE inhibitors may show an exaggerated pressor response to exogenous angiotensin II, because it bypasses the blocked conversion step and the system is sensitized. This can cause a greater blood pressure rise than expected.
What this interaction means in plain words
Captopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition reduces endogenous angiotensin II, increasing sensitivity to exogenous angiotensin II.
What to do
Start angiotensin II at the low end of the dosing range and titrate to blood pressure with continuous monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Captopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients on ACE inhibitors may show an exaggerated pressor response to exogenous angiotensin II, because it bypasses the blocked conversion step and the system is sensitized. This can cause a greater blood pressure rise than expected.
How serious is the interaction between Captopril and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start angiotensin II at the low end of the dosing range and titrate to blood pressure with continuous monitoring.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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