Drug interactions
Captopril + Thalidomide
Severity: Moderate
Captopril and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide can cause orthostatic hypotension and bradycardia. Added to captopril, it may increase the risk of low blood pressure and dizziness.
What this interaction means in plain words
Captopril and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Thalidomide belongs to Miscellaneous.
Why it happens
Additive hypotensive effects.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce antihypertensive dosing if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Thalidomide
Frequently asked questions
Can I take Captopril with Thalidomide?
MediHelp rates the interaction as moderate. Captopril and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide can cause orthostatic hypotension and bradycardia. Added to captopril, it may increase the risk of low blood pressure and dizziness.
How serious is the interaction between Captopril and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce antihypertensive dosing if symptomatic hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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